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Free Myleran Information :

Chemical Name : BUSULFAN - ORAL 0135 (byou-SULL-fan)

Common uses :

Busulfan is used to treat leukemia (CML) when stem cell transplant is not an option. Busulfan works by stopping cancer cells from multiplying, but also affects some normal cells, such as bone marrow cells. Busulfan is not a cure, but can cause cancer remission.

Possible side effects :

Nausea; diarrhea or constipation; headache, skin darkening, or flushing may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. Tell your doctor immediately if any of these serious side effects occur:
unusual tiredness, fast or irregular heartbeat, fever, persistent sore throat, easy bruising/bleeding, mental/mood changes, increased thirst, blurred vision, muscle cramps or weakness, chest pain, seizures, sudden weight gain or loss, stomach pain or swelling, change in amount or color of urine, mouth sores. Tell your doctor immediately if any of these unlikely but serious side effects occur:
dizziness, fainting, vomiting. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur:
dark urine, yellowing eyes/skin, coughing up blood, vision problems. An allergic reaction to Myleran is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include:
rash, itching, swelling, dizziness, trouble breathing. Rare, possibly fatal, lung problems may occur months to years after using busulfan. Symptoms include trouble breathing or persistent cough or congestion. Report any symptoms promptly. If your leukemia symptoms reoccur or worsen, notify your doctor immediately. Busulfan itself may infrequently cause cancer. If you notice other effects not listed above, contact your doctor or pharmacist.

Drug interactions :

Tell your doctor or pharmacist of all prescription and nonprescription drugs you may use, especially of:
azole antifungals (e.g., itraconazole,), thioguanine, acetaminophen, drugs that can cause seizures (e.g., bupropion), drugs that can increase seizure risk (e.g., phenothiazines such as chlorpromazine), other drugs which affect the bone marrow/immune system (e.g., other anti-cancer drugs, or cyclosporine). Check your prescription and nonprescription labels carefully for acetaminophen-containing products. These should be used cautiously 3 days before and during therapy with busulfan. Acetaminophen may increase busulfan blood levels and side effects. If acetaminophen is used, do not exceed recommended daily doses. Do not start or stop any medicine without doctor or pharmacist approval.

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